Better reproducibility in biology by better statistics 🥚 🥚 🥚
Table of Contents The replication crisis in biology Bad statistics, an example Replication fails How can we improve statistical analysis? Bayesian modeling as alternative statistics Checking against reality Extracting knowledge from the posterior Comparing first model fit and fit with replicate data Updating the model Where from here? In the following text I demonstrate a…
Bayesian Basics for Biologists (2): Bayesian Inference 🐧
A biological question: Has the penguin colony an abnormal sex ratio? – A large penguin colony (about five thousand birds) on an island in the South Atlantic has been exposed over the last years to certain chemicals that may act like hormones. We have the hypothesis that this exposure has led to a shift of…
Bayesian Basics for Biologists (1): Probability Distributions 🎲
Introducing probability distributions in biological context — We make biological experiments and observations to learn about biological systems, their components, their properties, and their relationships. Usually, biological systems are complex and variable. For instance, a mouse is a complex system consists of molecules that form cells that form tissues and organs that form the mouse.…